Clinical research brain scan depression treatment. Psilocybin Therapy for Depression: What the Clinical Trials Actually Show From the first open-label feasibility studies in 2016 to two Phase 3 successes announced in 2025 and 2026, the clinical evidence for psilocybin in depression has moved faster than almost any psychiatric treatment in modern history. Here is what the research actually shows — and what remains genuinely uncertain. Category: Research and Microdosing |...